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Compounds

COMPOUND NPA028545

STRUCTURE

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PROPERTIES

NPAID	NPA028545
CLUSTER ID	8531
NODE ID	5776
NAME	Leupeptazin
FORMULA	C21H38N8O3
MOLECULAR WEIGHT (Da)	450.5880
ACCURATE MASS (Da)	450.3067
ORIGIN ORGANISM TYPE	Bacterium
ORIGIN GENUS	Streptomyces
ORIGIN SPECIES	sp.
InChIKey	HARWFBRXTCPOLU-LUKYLMHMSA-N
InChI	InChI=1S/C21H38N8O3/c1-11(2)9-15(24-13(5)30)18(31)26-16(10-12(3)4)19(32)25-14-7-6-8-29-17(14)27-20(22)28-21(29)23/h11-12,14-17H,6-10H2,1-5H3,(H,24,30)(H,25,32)(H,26,31)(H4,22,23,27,28)/t14-,15-,16-,17+/m0/s1
SMILES	CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CCCN2C(N)=NC(N)=N[C@@H]12

ORIGINAL ISOLATION REFERENCE

CITATION	Kruglyak N; Williams DE; Chen H; Law S; Kaleta J; Villanueva I; Davies JE; Andersen RJ; Brömme D Leupeptazin, a highly modified tripeptide isolated from cultures of a Streptomyces sp. inhibits cathepsin K. Bioorganic and Medicinal Chemistry Letters 2017 27 (6) 1397-1400.
DOI	10.1016/j.bmcl.2017.02.007	PMID	28228366

ORIGINAL ISOLATION TAXONOMY

RANK	NAME	DB LINK	NCBI
Domain	Bacteria	LPSN	2
Phylum	Actinobacteria	LPSN	201174
Class	Actinobacteria	LPSN	-
Order	Streptomycetales	LPSN	85011
Family	Streptomycetaceae	LPSN	2062
Genus	Streptomyces	LPSN	1883

CLASSYFIRE

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DESCRIPTION	[[ getValue('description') ]]
KINGDOM	[[ getValue('kingdom') ]]
SUPER CLASS	[[ getValue('superclass') ]]
CLASS	[[ getValue('class') ]]
SUB CLASS	[[ getValue('subclass') ]]
MOLECULAR FRAMEWORK	[[ getValue('molecular_framework') ]]

NP CLASSIFIER

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SUPER CLASS	[[ getValue('superclass_results') ]]
CLASS	[[ getValue('class_results') ]]
PATHWAY	[[ getValue('pathway_results') ]]
IS GLYCOSIDE?	[[ getValue('isglycoside') ]]

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