Natural Products Atlas

ID	Spectrum Quality	Annotated Name
CCMSLIB00005435719	Bronze	Leucinostatin&A&M+H
CCMSLIB00005435705	Bronze	Leucinostatin&A&reference&standard
CCMSLIB00000577505	Gold	3
CCMSLIB00005777307	Gold	3
CCMSLIB00005777309	Gold	3
CCMSLIB00005777274	Gold	3
CCMSLIB00012119927	Gold	4
CCMSLIB00012119929	Gold	4
CCMSLIB00012119930	Gold	4
CCMSLIB00012119931	Gold	4
CCMSLIB00012119932	Gold	4
CCMSLIB00012119928	Gold	4
CCMSLIB00012119934	Gold	4
CCMSLIB00012119933	Gold	4
CCMSLIB00009959724	Gold	4
CCMSLIB00009959726	Gold	4
CCMSLIB00009959727	Gold	4
CCMSLIB00009959728	Gold	4
CCMSLIB00009959729	Gold	4
CCMSLIB00009959725	Gold	4
CCMSLIB00009959731	Gold	4
CCMSLIB00009959730	Gold	4

EXPORT OPTIONS	PNG JSON SDF
PROJECT MOLECULE TO GLOBAL VIEW	See Global

EXTERNAL LINKS

NPAID	NPA020029
CLUSTER ID	6377
NODE ID	141
NAME	Leucinostatin
FORMULA	C62H111N11O13
MOLECULAR WEIGHT (Da)	1218.6340
ACCURATE MASS (Da)	1217.8363
ORIGIN ORGANISM TYPE	Fungus
ORIGIN GENUS	Penicillium
ORIGIN SPECIES	lilacinum
InChIKey	FOAIGCPESMNWQP-FGFJWYLSSA-N
InChI	InChI=1S/C62H111N11O13/c1-21-38(9)23-24-49(77)73-33-40(11)31-47(73)55(82)66-46(30-39(10)29-43(75)32-42(74)22-2)53(80)68-50(51(78)37(7)8)56(83)70-61(15,16)58(85)67-44(27-35(3)4)52(79)65-45(28-36(5)6)54(81)69-62(17,18)59(86)71-60(13,14)57(84)63-26-25-48(76)64-41(12)34-72(19)20/h23-24,35-41,43-47,50-51,75,78H,21-22,25-34H2,1-20H3,(H,63,84)(H,64,76)(H,65,79)(H,66,82)(H,67,85)(H,68,80)(H,69,81)(H,70,83)(H,71,86)/b24-23+/t38-,39+,40-,41-,43+,44-,45-,46-,47-,50-,51+/m0/s1
SMILES	CCC(=O)C[C@H](O)C[C@@H](C)C[C@H](NC(=O)[C@@H]1C[C@H](C)CN1C(=O)/C=C/[C@@H](C)CC)C(=O)N[C@H](C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(=O)NC(C)(C)C(=O)NCCC(=O)N[C@@H](C)CN(C)C)[C@H](O)C(C)C

CITATION	Arai T; Mikami Y; Fukushima K; Utsumi T; Yazawa K A new antibiotic, leucinostatin, derived from Penicillium lilacinum Journal of Antibiotics 1973 26 (3) 157-61.
DOI	10.7164/antibiotics.26.157	PMID	4783199

RANK	NAME	DB LINK	NCBI
Domain	Eukarya	-	2759
Kingdom	Fungi	MycoBank	4751
Phylum	Ascomycota	MycoBank	4890
Class	Eurotiomycetes	MycoBank	147545
Order	Eurotiales	MycoBank	5042
Family	Aspergillaceae	MycoBank	1131492
Genus	Penicillium	MycoBank	5073

VERSION	SMILES	CITATION
Original Isolation	CC[C@@H](C)/C=C/C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H](C[C@H](C)CC(CC(=O)CC)O)C(=O)N[C@@H]([C@@H](C(C)C)O)C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(=O)NC(C)(C)C(=O)NCCC(=O)N[C@@H](C)CN(C)C)C	Arai T; Mikami Y; Fukushima K; Utsumi T; Yazawa K A new antibiotic, leucinostatin, derived from Penicillium lilacinum Journal of Antibiotics 1973 26 (3) 157-61. DOI: 10.7164/antibiotics.26.157 PMID: 4783199
2	CCC(=O)C[C@H](O)C[C@@H](C)C[C@H](NC(=O)[C@@H]1C[C@H](C)CN1C(=O)/C=C/[C@@H](C)CC)C(=O)N[C@H](C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(=O)NC(C)(C)C(=O)NCCC(=O)N[C@@H](C)CN(C)C)[C@H](O)C(C)C	Abe, Hikaru; Ouchi, Hitoshi; Sakashita, Chiharu; Kawada, Manabu; Watanabe, Takumi; Shibasaki, Masakatsu Catalytic Asymmetric Total Synthesis and Stereochemical Revision of Leucinostatin A: A Modulator of Tumor-Stroma Interaction. Chemistry - A European Journal 2017 23 (49) 11792-11796. DOI: 10.1002/chem.201703239 PMID: 28703358

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