Compounds
| ID | Spectrum Quality | Annotated Name |
|---|
COMPOUND NPA018950
PROPERTIES
| NPAID | NPA018950 |
|---|---|
| CLUSTER ID | 26 |
| NODE ID | 25 |
| NAME | Scytonemide A |
| FORMULA | C36H56N8O9 |
| MOLECULAR WEIGHT (Da) | 744.8910 |
| ACCURATE MASS (Da) | 744.4170 |
| ORIGIN ORGANISM TYPE | Bacterium |
| ORIGIN GENUS | Scytonema |
| ORIGIN SPECIES | hofmannii UTEX 1834 |
| InChIKey | HJKXQQVDTIEFDD-ADDJGAGCSA-N |
| InChI | InChI=1S/C36H56N8O9/c1-7-21(6)31-36(53)42-27(18-45)34(51)43-30(20(4)5)35(52)40-23(14-19(2)3)16-38-26(15-22-8-10-24(46)11-9-22)32(49)39-17-29(48)41-25(33(50)44-31)12-13-28(37)47/h8-11,16,19-21,23,25-27,30-31,45-46H,7,12-15,17-18H2,1-6H3,(H2,37,47)(H,39,49)(H,40,52)(H,41,48)(H,42,53)(H,43,51)(H,44,50)/t21-,23-,25+,26-,27-,30-,31-/m0/s1 |
| SMILES | CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C=N[C@H](C(=O)NCC(=O)N[C@@H](C(=O)N1)CCC(=O)N)CC2=CC=C(C=C2)O)CC(C)C)C(C)C)CO |
ORIGINAL ISOLATION REFERENCE
| CITATION | Krunic, Aleksej; Vallat, Armelle; Mo, Shunyan; Lantvit, Daniel D.; Swanson, Steven M.; Orjala, Jimmy Scytonemides A and B, cyclic peptides with 20S proteasome inhibitory activity from the cultured cyanobacterium scytonema hofmanii Journal of Natural Products 2010 73 (11) 1927-1932. | ||
|---|---|---|---|
| DOI | 10.1021/np100600z | PMID | 21058727 |
SYNTHESES
| CITATION 1 | Wilson TA; Tokarski RJ; Sullivan P; Demoret RM; Orjala J; Rakotondraibe LH; Fuchs JR Total Synthesis of Scytonemide A Employing Weinreb AM Solid-Phase Resin. Journal of Natural Products 2018 81 (3) 534-542. DOI: 10.1021/acs.jnatprod.7b00912 PMID: 29400964 | ||
|---|---|---|---|
