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Compounds

COMPOUND NPA015661

STRUCTURE
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EXTERNAL LINKS
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PROPERTIES
NPAID NPA015661
CLUSTER ID 1533
NODE ID 1260
NAME Phaeosphaeride A
FORMULA C15H23NO5
MOLECULAR WEIGHT (Da) 297.3510
ACCURATE MASS (Da) 297.1576
ORIGIN ORGANISM TYPE Fungus
ORIGIN GENUS Paraphaeosphaeria
ORIGIN SPECIES neglecta FT462
InChIKey PQXBZFLVJGBOAD-XEGUGMAKSA-N
InChI InChI=1S/C15H23NO5/c1-5-6-7-8-10-15(3,19)13(17)11-12(21-10)9(2)16(20-4)14(11)18/h10,13,17,19H,2,5-8H2,1,3-4H3/t10-,13-,15-/m0/s1
SMILES CCCCC[C@H]1[C@]([C@H](C2=C(O1)C(=C)N(C2=O)OC)O)(C)O
ORIGINAL ISOLATION REFERENCE
CITATION Maloney, Katherine N; Hao, Wenshan; Xu, Jun; Gibbons, Jay; Hucul, John; Roll, Deborah; Brady, Sean F; Schroeder, Frank C; Clardy, Jon Phaeosphaeride A, an inhibitor of STAT3-dependent signaling isolated from an endophytic fungus Organic Letters 2006 8 (18) 4067-4070.
DOI 10.1021/ol061556f PMID 16928075
ORIGINAL ISOLATION TAXONOMY
RANK NAME DB LINK NCBI
Domain Eukarya - 2759
Kingdom Fungi MycoBank 4751
Phylum Ascomycota MycoBank 4890
Class Dothideomycetes MycoBank 147541
Order Pleosporales MycoBank 92860
Family Didymosphaeriaceae MycoBank 221678
Genus Paraphaeosphaeria MycoBank 125369
SYNTHESES
CITATION 1 Kobayashi K; Okamoto I; Morita N; Kiyotani T; Tamura O Synthesis of the proposed structure of phaeosphaeride A. Organic & Biomolecular Chemistry 2011 9 (16) 5825-32. DOI: 10.1039/c1ob05612c PMID: 21727987
CITATION 2 Chatzimpaloglou A; Yavropoulou MP; Rooij KE; Biedermann R; Mueller U; Kaskel S; Sarli V Total synthesis and biological activity of the proposed structure of phaeosphaeride A. Journal of Organic Chemistry 2012 77 (21) 9659-67. DOI: 10.1021/jo301662e PMID: 23050677
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