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Compounds

COMPOUND NPA015043

STRUCTURE
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PROPERTIES
NPAID NPA015043
CLUSTER ID 394
NODE ID 11
NAME Chaetominine
FORMULA C22H18N4O4
MOLECULAR WEIGHT (Da) 402.4100
ACCURATE MASS (Da) 402.1328
ORIGIN ORGANISM TYPE Fungus
ORIGIN GENUS Chaetomium
ORIGIN SPECIES sp. IFB-E015
InChIKey GEURDGODABUDHB-TYTLQBBQSA-N
InChI InChI=1S/C22H18N4O4/c1-12-18(27)26-16-9-5-3-7-14(16)22(30)10-17(20(29)25(12)21(22)26)24-11-23-15-8-4-2-6-13(15)19(24)28/h2-9,11-12,17,21,30H,10H2,1H3/t12-,17+,21-,22-/m0/s1
SMILES C[C@H]1C(=O)N2[C@@H]3N1C(=O)[C@@H](C[C@@]3(C4=CC=CC=C42)O)N5C=NC6=CC=CC=C6C5=O
ORIGINAL ISOLATION REFERENCE
CITATION Jiao, Rui H; Xu, Shu; Liu, Jun Y; Ge, Hui M; Ding, Hui; Xu, Chen; Zhu, Hai L; Tan, Ren X Chaetominine, a cytotoxic alkaloid produced by endophytic Chaetomium sp. IFB-E015 Organic Letters 2006 8 (25) 5709-5712.
DOI 10.1021/ol062257t PMID 17134253
ORIGINAL ISOLATION TAXONOMY
RANK NAME DB LINK NCBI
Domain Eukarya - 2759
Kingdom Fungi MycoBank 4751
Phylum Ascomycota MycoBank 4890
Class Sordariomycetes MycoBank 147550
Order Sordariales MycoBank 5139
Family Chaetomiaceae MycoBank 35718
Genus Chaetomium MycoBank 5149
SYNTHESES
CITATION 1 Toumi M; Couty F; Marrot J; Evano G Total synthesis of chaetominine. Organic Letters 2008 10 (21) 5027-30. DOI: 10.1021/ol802155n PMID: 18847212
CITATION 2 Malgesini B; Forte B; Borghi D; Quartieri F; Gennari C; Papeo G A straightforward total synthesis of (-)-chaetominine. Chemistry - A European Journal 2009 15 (32) 7922-9. DOI: 10.1002/chem.200900793 PMID: 19562787
CITATION 3 Peng QL; Luo SP; Xia XE; Liu LX; Huang PQ The four-step total synthesis of (-)-chaetominine. Chemical Communications 2014 50 (16) 1986-8. DOI: 10.1039/c3cc48833k PMID: 24413776
CITATION 4 Geng H; Huang PQ Rapid Generation of Molecular Complexity by Chemical Synthesis: Highly Efficient Total Synthesis of Hexacyclic Alkaloid (-)-Chaetominine and Its Biosynthetic Implications. Chemical Record 2019 19 (2-3) 523-533. DOI: 10.1002/tcr.201800079 PMID: 30252197
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