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Compounds

COMPOUND NPA007442

STRUCTURE
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PROPERTIES
NPAID NPA007442
CLUSTER ID 3326
NODE ID 2521
NAME Antillatoxin
FORMULA C28H45N3O5
MOLECULAR WEIGHT (Da) 503.6840
ACCURATE MASS (Da) 503.3359
ORIGIN ORGANISM TYPE Bacterium
ORIGIN GENUS Lyngbya
ORIGIN SPECIES majuscula
InChIKey WNMROEVYEZDXEL-OITYILOZSA-N
InChI InChI=1S/C28H45N3O5/c1-16(2)24-26(34)29-15-23(33)36-25(19(5)12-17(3)14-28(8,9)10)20(6)18(4)13-22(32)30-21(7)27(35)31(24)11/h12,14,16,20-21,24-25H,4,13,15H2,1-3,5-11H3,(H,29,34)(H,30,32)/b17-14+,19-12+/t20-,21+,24+,25+/m1/s1
SMILES C[C@H]1[C@@H](OC(=O)CNC(=O)[C@@H](N(C(=O)[C@@H](NC(=O)CC1=C)C)C)C(C)C)/C(=C/C(=C/C(C)(C)C)/C)/C
ORIGINAL ISOLATION REFERENCE
CITATION Orjala, Jimmy; Nagle, Dale. G.; Hsu, Victor.; Gerwick, William H. Antillatoxin: An Exceptionally Ichthyotoxic Cyclic Lipopeptide from the Tropical Cyanobacterium Lyngbya majuscula Journal of the American Chemical Society 1995 117 (31) 8281-8282.
DOI 10.1021/ja00136a031 PMID -
ORIGINAL ISOLATION TAXONOMY
RANK NAME DB LINK NCBI
Domain Bacteria LPSN 2
Phylum Cyanobacteria LPSN 1117
Class Cyanophyceae LPSN -
Order Oscillatoriales LPSN 1150
Family Oscillatoriaceae LPSN 1892254
Genus Lyngbya LPSN 28073
SYNTHESES
CITATION 1 Lee KC; Loh TP Total synthesis of antillatoxin. Chemical Communications 2006 (40) 4209-11. DOI: 10.1039/b608193m PMID: 17031434
CITATION 2 Okura K; Matsuoka S; Goto R; Inoue M The twisted side chain of antillatoxin is important for potent toxicity: total synthesis and biological evaluation of antillatoxin and analogues. Angewandte Chemie International Edition 2010 49 (2) 329-32. DOI: 10.1002/anie.200905892 PMID: 19998300
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