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Compounds

COMPOUND NPA007264

STRUCTURE
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PROJECT MOLECULE TO GLOBAL VIEW See Global
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PROPERTIES
NPAID NPA007264
CLUSTER ID 3259
NODE ID 11
NAME K-252c
FORMULA C20H13N3O
MOLECULAR WEIGHT (Da) 311.3440
ACCURATE MASS (Da) 311.1059
ORIGIN ORGANISM TYPE Bacterium
ORIGIN GENUS Nocardiopsis
ORIGIN SPECIES sp. K-252
InChIKey MEXUTNIFSHFQRG-UHFFFAOYSA-N
InChI InChI=1S/C20H13N3O/c24-20-17-12(9-21-20)15-10-5-1-3-7-13(10)22-18(15)19-16(17)11-6-2-4-8-14(11)23-19/h1-8,22-23H,9H2,(H,21,24)
SMILES C1C2=C3C4=CC=CC=C4NC3=C5C(=C2C(=O)N1)C6=CC=CC=C6N5
ORIGINAL ISOLATION REFERENCE
CITATION Yasuzawa, T; Iida, T; Yoshida, M; Hirayama, N; Takahashi, M; Shirahata, K; Sano, H The structures of the novel protein kinase C inhibitors K-252a, b, c and d Journal of Antibiotics 1986 39 (8) 1072-1078.
DOI 10.7164/antibiotics.39.1072 PMID 3759659
ORIGINAL ISOLATION TAXONOMY
RANK NAME DB LINK NCBI
Domain Bacteria LPSN 2
Phylum Actinobacteria LPSN 201174
Class Actinobacteria LPSN -
Order Streptosporangiales LPSN 85012
Family Nocardiopsaceae LPSN 83676
Genus Nocardiopsis LPSN 2013
SYNTHESES
CITATION 1 Mahboobi S; Eibler E; Koller M; Kumar KC S; Popp A; Schollmeyer D Synthesis of Pyrrolidin-2-ones and of Staurosporine Aglycon (K-252c) by Intermolecular Michael Reaction. Journal of Organic Chemistry 1999 64 (13) 4697-4704. DOI: 10.1021/jo9825106 PMID: 11674542
CITATION 2 Fox JC; Gilligan RE; Pitts AK; Bennett HR; Gaunt MJ The total synthesis of K-252c (staurosporinone) Chemical Science 2016 7 (4) 2706-2710. DOI: 10.1039/c5sc04399a PMID: 28660044
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